ATE30235T1 - Antiinflammatorische produkte von methylendiphosphonsaeure abgeleitet und verfahren zu ihrer herstellung. - Google Patents
Antiinflammatorische produkte von methylendiphosphonsaeure abgeleitet und verfahren zu ihrer herstellung.Info
- Publication number
- ATE30235T1 ATE30235T1 AT83401520T AT83401520T ATE30235T1 AT E30235 T1 ATE30235 T1 AT E30235T1 AT 83401520 T AT83401520 T AT 83401520T AT 83401520 T AT83401520 T AT 83401520T AT E30235 T1 ATE30235 T1 AT E30235T1
- Authority
- AT
- Austria
- Prior art keywords
- methylene
- manufacture
- products derived
- inflammatory products
- diphosphone acid
- Prior art date
Links
- 239000002253 acid Substances 0.000 title 1
- 230000003110 anti-inflammatory effect Effects 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 125000001570 methylene group Chemical class [H]C([H])([*:1])[*:2] 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
- C07F9/6539—Five-membered rings
- C07F9/6541—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3865—Polyphosphonic acids containing sulfur substituents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4025—Esters of poly(thio)phosphonic acids
- C07F9/4043—Esters of poly(thio)phosphonic acids containing sulfur substituents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/58—Pyridine rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6503—Five-membered rings
- C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
- C07F9/65068—Five-membered rings having the nitrogen atoms in positions 1 and 3 condensed with carbocyclic rings or carbocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Rheumatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Pain & Pain Management (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8213250A FR2531088B1 (fr) | 1982-07-29 | 1982-07-29 | Produits anti-inflammatoires derives de l'acide methylenediphosphonique et leur procede de preparation |
| EP83401520A EP0100718B1 (fr) | 1982-07-29 | 1983-07-25 | Produits anti-inflammatoires dérivés de l'acide méthylène-diphosphonique et leur procédé de préparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE30235T1 true ATE30235T1 (de) | 1987-10-15 |
Family
ID=9276447
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT83401520T ATE30235T1 (de) | 1982-07-29 | 1983-07-25 | Antiinflammatorische produkte von methylendiphosphonsaeure abgeleitet und verfahren zu ihrer herstellung. |
Country Status (35)
| Country | Link |
|---|---|
| US (2) | US4746654A (en]) |
| EP (1) | EP0100718B1 (en]) |
| JP (1) | JPS5942395A (en]) |
| KR (1) | KR910000726B1 (en]) |
| AR (2) | AR242394A1 (en]) |
| AT (1) | ATE30235T1 (en]) |
| AU (1) | AU566880B2 (en]) |
| CA (1) | CA1267650A (en]) |
| CS (1) | CS252463B2 (en]) |
| CZ (1) | CZ419191A3 (en]) |
| DD (1) | DD213670A5 (en]) |
| DE (1) | DE3374062D1 (en]) |
| DK (1) | DK170342B1 (en]) |
| DZ (1) | DZ562A1 (en]) |
| EG (1) | EG15968A (en]) |
| ES (1) | ES524495A0 (en]) |
| FI (1) | FI75830C (en]) |
| FR (1) | FR2531088B1 (en]) |
| GR (1) | GR79597B (en]) |
| HU (1) | HU190454B (en]) |
| IE (1) | IE56343B1 (en]) |
| IL (1) | IL69347A (en]) |
| LU (1) | LU88723I2 (en]) |
| MA (1) | MA19858A1 (en]) |
| NL (1) | NL960007I2 (en]) |
| NO (2) | NO164712C (en]) |
| NZ (1) | NZ205061A (en]) |
| OA (1) | OA07507A (en]) |
| PH (1) | PH22082A (en]) |
| PL (2) | PL142022B1 (en]) |
| PT (1) | PT77122B (en]) |
| SG (1) | SG18588G (en]) |
| SU (2) | SU1333240A3 (en]) |
| YU (1) | YU45143B (en]) |
| ZA (1) | ZA835578B (en]) |
Families Citing this family (105)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2558837B1 (fr) * | 1984-01-26 | 1986-06-27 | Sanofi Sa | Derives de l'acide methylenediphosphonique, procede d'obtention et medicaments antirhumatismaux les contenant |
| PH27078A (en) * | 1984-12-21 | 1993-02-01 | Procter & Gamble | Pharmaceutical compositions containing geminal diphosphonates |
| IL77243A (en) * | 1984-12-21 | 1996-11-14 | Procter & Gamble | Pharmaceutical compositions containing geminal diphosphonic acid compounds and certain such novel compounds |
| US5641762A (en) * | 1985-05-02 | 1997-06-24 | Research Corporation Technologies, Inc. | Bone targeted inhibitors of carbonic anhydrase |
| US4761406A (en) * | 1985-06-06 | 1988-08-02 | The Procter & Gamble Company | Regimen for treating osteoporosis |
| US4902679A (en) * | 1985-12-13 | 1990-02-20 | Norwich Eaton Pharmaceuticals, Inc. | Methods of treating diseases with certain geminal diphosphonates |
| DE3770982D1 (de) * | 1986-04-24 | 1991-08-01 | Fujisawa Pharmaceutical Co | Diphosphonsaeure-verbindungen, verfahren zu deren herstellung und sie enthaltende arzneimittel. |
| IL84731A0 (en) * | 1986-12-19 | 1988-05-31 | Norwich Eaton Pharma | Heterocycle-substituted diphosphonic acids and salts and esters and pharmaceutical compositions containing them |
| KR880011136A (ko) * | 1987-03-11 | 1988-10-26 | 모리오까 시게오 | 아졸- 아미노메틸렌 비스포스폰산 유도체 |
| IL86951A (en) * | 1987-07-06 | 1996-07-23 | Procter & Gamble Pharma | Methylene phosphonoalkylphosphinates and pharmaceutical preparations containing them |
| DE3805663A1 (de) * | 1988-02-24 | 1989-09-07 | Henkel Kgaa | Oxaalkanpolyphosphonsaeuren, ihre verwendung als thresholder sowie diese verbindungen enthaltende, komplexierend wirkende zusammensetzungen |
| CH675422A5 (en]) * | 1988-03-31 | 1990-09-28 | Symphar Sa | |
| FR2629716B1 (fr) * | 1988-04-07 | 1991-07-19 | Sanofi Sa | Composition pharmaceutique pour administration orale a base d'un derive d'acide diphosphonique |
| DE3822650A1 (de) * | 1988-07-05 | 1990-02-01 | Boehringer Mannheim Gmbh | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
| RU2091311C1 (ru) * | 1988-11-01 | 1997-09-27 | Арч Дивелопмент Корпорейшн | Способ извлечения ионов металла |
| US5154843A (en) * | 1989-02-08 | 1992-10-13 | The Lubrizol Corporation | Hydroxyalkane phosphonic acids and derivatives thereof and lubricants containing the same |
| PH26923A (en) * | 1989-03-08 | 1992-12-03 | Ciba Geigy | N-substituted amino alkanediphosphonic acids |
| US5220021A (en) * | 1989-04-03 | 1993-06-15 | The Upjohn Company | Geminal bisphosphonic acids and derivatives as anti-arthritic agents |
| JPH0377894A (ja) * | 1989-08-18 | 1991-04-03 | Toray Ind Inc | メチレンジホスホン酸化合物 |
| EP0416689B1 (en) * | 1989-09-06 | 1995-11-29 | Merck & Co. Inc. | Acyloxymethyl esters of bisphosphonic acids as bone resorption inhibitors |
| DE59107135D1 (de) * | 1990-01-18 | 1996-02-08 | Ciba Geigy Ag | Phoshponsäure- und Thionophosphonsäure-Derivate |
| IE912115A1 (en) * | 1990-06-25 | 1992-01-01 | Takeda Chemical Industries Ltd | Bisphosphonic acid derivatives, their production and use |
| ES2072015T3 (es) * | 1990-08-21 | 1995-07-01 | Upjohn Co | Derivados del acido bisfosfonico como agente anti-artritico. |
| EP0561948B1 (en) * | 1990-12-07 | 1995-04-05 | The Upjohn Company | Phosphonic acid derivatives useful as antiinflammatory agents |
| DE69116838T2 (de) * | 1990-12-19 | 1996-06-13 | Takeda Chemical Industries Ltd | Bisphosphonsäurederivate, ihre Produktion und ihre Verwendung |
| IT1244698B (it) * | 1991-02-01 | 1994-08-08 | Gentili Ist Spa | Acidi aril-o arilalchil-acil ammino-alchil-idrossidifosfonici, procedimento per la loro preparazione e loro uso in terapia osteo-articolare e dei tessuti connettori in generale |
| DE69224830D1 (en) * | 1991-06-19 | 1998-04-23 | Upjohn Co | Dialkyl (dialkoxyphosphinyl)methyl phosphate als antientzündungsmittel |
| EP0521622B1 (en) * | 1991-07-03 | 1997-08-13 | PHARMACIA & UPJOHN COMPANY | Pyrazolopyrimidine and pyrimidinyl bisphosphonic esters as anti-inflammatories |
| EP0594857B1 (en) * | 1991-09-05 | 1998-04-29 | Toray Industries, Inc. | Methanediphosphonic acid derivative, production thereof and medicinal use thereof |
| EP0541037A3 (en) * | 1991-11-06 | 1997-02-26 | Takeda Chemical Industries Ltd | Squalene synthetase inhibitory composition and use thereof |
| JPH06172372A (ja) * | 1991-11-06 | 1994-06-21 | Takeda Chem Ind Ltd | スクアレン合成酵素阻害剤およびその用途 |
| JPH07506569A (ja) * | 1992-05-29 | 1995-07-20 | プロクター、エンド、ギャンブル、ファーマスーティカルズ、インコーポレーテッド | 異常カルシウム及びリン酸代謝と歯石及び歯垢を治療するための四級窒素含有ホスホネート化合物 |
| US5391743A (en) * | 1992-05-29 | 1995-02-21 | Procter & Gamble Pharmaceuticals, Inc. | Quaternary nitrogen-containing phosphonate compounds, pharmaceutical compositions, and methods of treating abnormal calcium and phosphate metabolism and methods of treating and preventing dental calculus and plaque |
| CZ296794A3 (en) * | 1992-05-29 | 1995-04-12 | Procter & Gamble Pharma | Phosphonate sulfur-containing compounds and their use in the preparation of a pharmaceutical for treating abnormal metabolism of calcium and phosphate |
| US5753634A (en) * | 1992-05-29 | 1998-05-19 | The Procter & Gamble Company | Quaternary nitrogen containing phosphonate compounds, pharmaceutical compostions, and methods for treating abnormal calcium and phosphate metabolism |
| KR100266484B1 (ko) * | 1992-05-29 | 2000-09-15 | 제이코버스 코넬리스 레이서 | 칼슘및인산염의이상대사를치료하기위한티오-치환된질소-함유헤테로사이클릭포스포네이트화합물 |
| US5763611A (en) * | 1992-05-29 | 1998-06-09 | The Procter & Gamble Company | Thio-substituted cyclic phosphonate compounds, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism |
| RU2119794C1 (ru) * | 1992-06-30 | 1998-10-10 | Проктер энд Гэмбл Фармасьютикалз, Инк. | Использование фосфонатов и нестероидных противовоспалительных лекарственных средств для лечения артрита, способ лечения |
| ES2155446T3 (es) * | 1992-07-10 | 2001-05-16 | Toray Industries | Derivado de metanodifosfonato, su produccion y su uso farmaceutico. |
| GB9215433D0 (en) * | 1992-07-21 | 1992-09-02 | Cmb Foodcan Plc | Apparatus for stripping a drawn article from a punch |
| FR2694558B1 (fr) * | 1992-08-05 | 1994-10-28 | Sanofi Elf | Monohydrate du sel disodique de l'acide 4-chlorophénylthiométhylène bisphosphonique, sa préparation, les compositions pharmaceutiques en contenant. |
| DE69313291D1 (de) * | 1992-08-07 | 1997-09-25 | Upjohn Co | Phosphonoessigsäure und ester als antientzündungsmittel |
| AU4859493A (en) * | 1992-10-09 | 1994-05-09 | Upjohn Company, The | Pyrimidine bisphosphonate esters and (alkoxymethylphosphinyl)alkyl phosphonic acids as anti-inflammatories |
| JPH06135976A (ja) * | 1992-10-30 | 1994-05-17 | Toray Ind Inc | メタンジホスホン酸誘導体、その製造方法およびその医薬用途 |
| US5332728A (en) * | 1992-11-23 | 1994-07-26 | Bristol-Myers Squibb Company | Method for treating a fungal infection |
| AU670337B2 (en) | 1992-11-30 | 1996-07-11 | Novartis Ag | Use of certain methanebisphosphonic acid derivatives in fracture healing |
| US6399592B1 (en) | 1992-12-23 | 2002-06-04 | Merck & Co., Inc. | Bishphosphonate/estrogen synergistic therapy for treating and preventing bone loss |
| WO1994019359A1 (en) * | 1993-02-25 | 1994-09-01 | Toray Industries, Inc. | Process for producing methanediphosphonate compound |
| FR2703590B1 (fr) * | 1993-04-05 | 1995-06-30 | Sanofi Elf | Utilisation de derives d'acide bisphosphonique pour la preparation de medicaments destines a favoriser la reparation osseuse . |
| US5854227A (en) * | 1994-03-04 | 1998-12-29 | Hartmann; John F. | Therapeutic derivatives of diphosphonates |
| US20010007863A1 (en) * | 1998-06-18 | 2001-07-12 | Merck & Co., Inc. | Wet granulation formulation for bisphosphonic acids |
| US5886206A (en) * | 1994-08-24 | 1999-03-23 | Toray Industries, Inc. | Process for production of methanediphosphonic acid compound |
| EP0831756A1 (en) | 1995-06-06 | 1998-04-01 | Merck & Co., Inc. | Bisphosphonate cement composition to prevent aseptic loosening of orthopedic implant devices |
| US5880111A (en) * | 1995-06-07 | 1999-03-09 | Farcasiu; Dan | Therapeutic derivations of diphosphonates |
| PT854724E (pt) * | 1995-09-29 | 2005-08-31 | Novartis Ag | Metodo de tratar a doenca navicular em cavalos |
| CA2267984A1 (en) * | 1996-10-09 | 1998-04-16 | Elizanor Biopharmaceuticals, Inc. | Diphosphonate therapeutic compounds |
| US8586781B2 (en) | 1998-04-02 | 2013-11-19 | Mbc Pharma, Inc. | Bone targeted therapeutics and methods of making and using the same |
| CN1215076C (zh) * | 1998-09-09 | 2005-08-17 | 症变治疗公司 | 新的果糖1,6－二磷酸酶的杂芳族抑制剂 |
| FR2784031B1 (fr) * | 1998-10-02 | 2002-02-01 | Sanofi Elf | Utilisation de derives de l'acide bisphosphonique pour la preparation d'un medicament destine au traitement des boiteries |
| WO2000038693A1 (fr) * | 1998-12-25 | 2000-07-06 | Toray Industries, Inc. | Inhibiteurs de la production d'interleukine-6 |
| DE60041876D1 (de) | 1999-07-23 | 2009-05-07 | Philadelphia Children Hospital | Polyurethanderivatzusammensetzungen und Verfahren zu ihrer Herstellung |
| AR021347A1 (es) * | 1999-10-20 | 2002-07-17 | Cipla Ltd | Una composicion farmaceutica que contiene acido(s) bisfosfoncio o sal(es) del mismo y un proceso de preparacion de la misma |
| US6420384B2 (en) | 1999-12-17 | 2002-07-16 | Ariad Pharmaceuticals, Inc. | Proton pump inhibitors |
| WO2001047935A2 (en) * | 1999-12-22 | 2001-07-05 | Metabasis Therapeutics, Inc. | Novel bisamidate phosphonate prodrugs |
| US6677320B2 (en) | 2000-01-20 | 2004-01-13 | Hoffmann-La Roches Inc. | Parenteral bisphosphonate composition with improved local tolerance |
| US7563774B2 (en) | 2000-06-29 | 2009-07-21 | Metabasis Therapeutics, Inc. | Combination of FBPase inhibitors and antidiabetic agents useful for the treatment of diabetes |
| CA2443857C (en) * | 2001-04-10 | 2012-06-26 | Mbc Research, Inc. | Bisphosphonate conjugates and methods of making and using the same |
| US6558702B2 (en) * | 2001-04-13 | 2003-05-06 | Alkermes Controlled Therapeutics, Inc. | Method of modifying the release profile of sustained release compositions |
| US20060269602A1 (en) * | 2001-04-13 | 2006-11-30 | Dasch James R | Method of modifying the release profile of sustained release compositions |
| TWI315982B (en) * | 2001-07-19 | 2009-10-21 | Novartis Ag | Combinations comprising epothilones and pharmaceutical uses thereof |
| JP2005514400A (ja) * | 2001-12-21 | 2005-05-19 | ザ プロクター アンド ギャンブル カンパニー | 骨疾患の治療方法 |
| US20050070504A1 (en) * | 2001-12-21 | 2005-03-31 | The Procter & Gamble Co. | Risedronate compositions and their methods of use |
| JP4502641B2 (ja) * | 2002-01-24 | 2010-07-14 | ティルタン ファーマ リミテッド | 抗癌組み合わせおよびその使用方法 |
| US20050176685A1 (en) * | 2002-04-05 | 2005-08-11 | Daifotis Anastasia G. | Method for inhibiting bone resorption with an alendronate and vitamin d formulation |
| EP2308563A1 (en) | 2002-05-10 | 2011-04-13 | F. Hoffmann-La Roche AG | Risedronic acid for treatment and prevention of bone resorption diseases |
| AU2003233731A1 (en) * | 2002-06-06 | 2003-12-22 | Xavier Billot | 1,5-disubstituted imidazolidin-2-one derivatives for use as ep4 receptor agonists in the treatment of eye and bone diseases |
| AU2003276990A1 (en) * | 2002-09-26 | 2004-04-19 | The Children's Hospital Of Philadelphia | Derivatized polyurethane compositions which exhibit enhanced stability in biological systems and methods of making the same |
| US20040138180A1 (en) * | 2002-10-03 | 2004-07-15 | Barr Laboratories, Inc. | Bisphosphonate composition and process for the preparation thereof |
| SI1790347T1 (sl) | 2002-12-20 | 2015-03-31 | F. Hoffmann-La Roche Ag | Formulacija z visokim odmerkom ibandronata |
| US7408014B2 (en) | 2003-07-08 | 2008-08-05 | The Children's Hospital Of Philadelphia | Steroid lipid-modified polyurethane as an implantable biomaterial, the preparation and uses thereof |
| CN1839114A (zh) | 2003-08-21 | 2006-09-27 | 默克弗罗斯特加拿大有限公司 | 组织蛋白酶半胱氨酸蛋白酶抑制剂 |
| BRPI0414565A (pt) * | 2003-09-19 | 2006-11-07 | Pfizer Prod Inc | composições farmacêuticas e métodos que compreendem combinações de derivados de 2-alquilideno-19-nor-vitamina d e um bisfosfonato |
| US20050261250A1 (en) * | 2004-05-19 | 2005-11-24 | Merck & Co., Inc., | Compositions and methods for inhibiting bone resorption |
| HRP20100583T1 (hr) | 2004-05-24 | 2010-12-31 | Warner Chilcott Company | Enterički čvrsti oralni oblik za doziranje od bisfosfonata koji sadrži kelatni agens |
| UA87854C2 (en) | 2004-06-07 | 2009-08-25 | Мерк Энд Ко., Инк. | N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators |
| BRPI0514372A (pt) * | 2004-08-18 | 2008-06-10 | Metabasis Therapeutics Inc | inibidores de tiazol de frutose 1, 6-bisfosfatase |
| US8697139B2 (en) | 2004-09-21 | 2014-04-15 | Frank M. Phillips | Method of intervertebral disc treatment using articular chondrocyte cells |
| CA2599572A1 (en) | 2005-03-02 | 2007-04-26 | Merck & Co., Inc. | Composition for inhibition of cathepsin k |
| NZ561666A (en) * | 2005-03-17 | 2010-05-28 | Elan Pharma Int Ltd | Nanoparticulate biphosphonate compositions |
| AU2006226818B2 (en) * | 2005-03-24 | 2011-05-12 | Medtronic, Inc. | Modification of thermoplastic polymers |
| WO2009082437A2 (en) | 2007-12-21 | 2009-07-02 | Ligand Pharmaceuticals Incorporated | Selective androgen receptor modulators (sarms) and uses thereof |
| WO2010019511A2 (en) | 2008-08-13 | 2010-02-18 | Targanta Therapeutics Corp. | Phosphonated rifamycins and uses thereof for the prevention and treatment of bone and joint infections |
| WO2010143193A1 (en) | 2009-06-11 | 2010-12-16 | Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. | Targeted liposomes comprising n-containing bisphosphonates and uses thereof |
| FR2954320B1 (fr) | 2009-12-17 | 2012-06-15 | Cll Pharma | Composition pharmaceutique orale suprabiodisponible contenant un acide biphosphonique ou un de ses sels |
| US8791162B2 (en) | 2011-02-14 | 2014-07-29 | Merck Sharp & Dohme Corp. | Cathepsin cysteine protease inhibitors |
| EP2731591B1 (en) | 2011-07-13 | 2020-06-17 | Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. | Liposomes co-encapsulating a bisphosphonate and an amphipathic agent |
| RU2640582C2 (ru) | 2011-08-01 | 2018-01-10 | Мбс Фарма, Инк. | Производные витамина в6 нуклеотидов, ациклических нуклеотидов и ациклических нуклеозидных фосфонатов |
| GB201200868D0 (en) | 2012-01-19 | 2012-02-29 | Depuy Int Ltd | Bone filler composition |
| WO2015051479A1 (en) | 2013-10-08 | 2015-04-16 | Merck Sharp & Dohme Corp. | Cathepsin cysteine protease inhibitors |
| JP6454335B2 (ja) | 2013-10-08 | 2019-01-16 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | カテプシンシステインプロテアーゼ阻害剤 |
| WO2015120580A1 (en) | 2014-02-11 | 2015-08-20 | Merck Sharp & Dohme Corp. | Cathepsin cysteine protease inhibitors |
| PL407922A1 (pl) | 2014-04-16 | 2015-10-26 | Wrocławskie Centrum Badań Eit + Spółka Z Ograniczoną Odpowiedzialnością | Nowe bisfosfoniany i ich zastosowanie |
| AU2015265571A1 (en) | 2014-05-30 | 2016-11-17 | Pfizer Inc. | Carbonitrile derivatives as selective androgen receptor modulators |
| CA3133929A1 (en) | 2019-04-19 | 2020-10-22 | Lin Zhi | Crystalline forms and methods of producing crystalline forms of a compound |
| WO2023275715A1 (en) | 2021-06-30 | 2023-01-05 | Pfizer Inc. | Metabolites of selective androgen receptor modulators |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1302557B (en]) * | 1963-04-09 | 1971-08-26 | ||
| US3705191A (en) * | 1970-04-13 | 1972-12-05 | Monsanto Co | Substituted ethane diphosphonic acids and salts and esters thereof |
| US3957858A (en) * | 1970-04-13 | 1976-05-18 | Monsanto Company | Substituted ethane diphosphonic acids and salts and esters thereof |
| US3654151A (en) * | 1970-04-13 | 1972-04-04 | Monsanto Co | Deflocculation of solid materials in aqueous medium |
| US3683080A (en) * | 1970-08-28 | 1972-08-08 | Procter & Gamble | Compositions for inhibiting anomalous deposition and mobilization of calcium phosphate in animal tissue |
| US4171373A (en) * | 1974-01-07 | 1979-10-16 | William H. Rorer, Inc. | Ethynylbenzene compounds and derivatives thereof to treat pain, fever and inflammation |
| US4071584A (en) * | 1977-01-03 | 1978-01-31 | Monsanto Company | Hydroxyphenylthiophosphoranylidene organophosphorus compounds |
| US4264582A (en) * | 1978-07-31 | 1981-04-28 | The Procter & Gamble Company | Isobutylphenylacetate anti-inflammatory composition |
| JPS5598193A (en) * | 1979-01-22 | 1980-07-25 | Nissan Chem Ind Ltd | Methylenediphosphonic acid derivative and herbicide comprising it as active constituent |
| GB2043072B (en) * | 1979-02-13 | 1983-11-23 | Symphar Sa | Diphosphonate compounds |
| US4330530A (en) * | 1980-12-22 | 1982-05-18 | The Procter & Gamble Company | Anti-arthritic compositions and method using gold salts and organophosphonates |
| DE3365492D1 (en) * | 1982-01-27 | 1986-10-02 | Schering Ag | Diphosphonic acid derivatives and pharmaceutical preparations containing them |
-
1982
- 1982-07-29 FR FR8213250A patent/FR2531088B1/fr not_active Expired
-
1983
- 1983-07-21 IE IE1716/83A patent/IE56343B1/en not_active IP Right Cessation
- 1983-07-22 DK DK336783A patent/DK170342B1/da not_active IP Right Cessation
- 1983-07-25 DE DE8383401520T patent/DE3374062D1/de not_active Expired
- 1983-07-25 EP EP83401520A patent/EP0100718B1/fr not_active Expired
- 1983-07-25 AT AT83401520T patent/ATE30235T1/de active
- 1983-07-25 LU LU88723C patent/LU88723I2/fr unknown
- 1983-07-25 NO NO832701A patent/NO164712C/no not_active IP Right Cessation
- 1983-07-26 IL IL69347A patent/IL69347A/xx not_active IP Right Cessation
- 1983-07-26 CA CA000433224A patent/CA1267650A/en not_active Expired - Lifetime
- 1983-07-27 PH PH29310A patent/PH22082A/en unknown
- 1983-07-27 GR GR72051A patent/GR79597B/el unknown
- 1983-07-27 AU AU17324/83A patent/AU566880B2/en not_active Expired
- 1983-07-28 OA OA58074A patent/OA07507A/xx unknown
- 1983-07-28 NZ NZ205061A patent/NZ205061A/en unknown
- 1983-07-28 MA MA20079A patent/MA19858A1/fr unknown
- 1983-07-28 KR KR1019830003523A patent/KR910000726B1/ko not_active Expired
- 1983-07-28 PT PT77122A patent/PT77122B/pt unknown
- 1983-07-28 ES ES524495A patent/ES524495A0/es active Granted
- 1983-07-28 HU HU832658A patent/HU190454B/hu unknown
- 1983-07-29 JP JP58139324A patent/JPS5942395A/ja active Granted
- 1983-07-29 SU SU833628775A patent/SU1333240A3/ru active
- 1983-07-29 PL PL1983259142A patent/PL142022B1/pl unknown
- 1983-07-29 FI FI832758A patent/FI75830C/fi not_active IP Right Cessation
- 1983-07-29 YU YU1600/83A patent/YU45143B/xx unknown
- 1983-07-29 PL PL1983243229A patent/PL141316B1/pl unknown
- 1983-07-29 ZA ZA835578A patent/ZA835578B/xx unknown
- 1983-07-29 DD DD83253536A patent/DD213670A5/de not_active IP Right Cessation
- 1983-07-29 CS CS835688A patent/CS252463B2/cs unknown
- 1983-07-30 EG EG468/83A patent/EG15968A/xx active
- 1983-11-27 DZ DZ836911A patent/DZ562A1/fr active
-
1984
- 1984-06-26 SU SU843754451A patent/SU1367859A3/ru active
-
1985
- 1985-06-11 AR AR85300673A patent/AR242394A1/es active
- 1985-06-11 AR AR85300674A patent/AR242393A1/es active
-
1986
- 1986-04-24 US US06/858,573 patent/US4746654A/en not_active Expired - Lifetime
-
1988
- 1988-03-07 US US07/165,080 patent/US4876248A/en not_active Expired - Lifetime
- 1988-03-23 SG SG185/88A patent/SG18588G/en unknown
-
1991
- 1991-12-31 CZ CS914191A patent/CZ419191A3/cs unknown
-
1996
- 1996-04-24 NL NL960007C patent/NL960007I2/nl unknown
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1998
- 1998-03-06 NO NO1998011C patent/NO1998011I1/no unknown
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